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Hemolytic Streptococcus Toxins and Antitoxins

II. Titration by Rabbit Intradermal and Ear Tests

From the Antitoxin and Vaccine Laboratory of the Massachusetts Department of Public Health

Abstract

Identical mixtures of scarlet fever streptococcus toxin and antitoxin have been injected subcutaneously in the ear and intracutaneously in the body of rabbits selected as reactive to this toxin.

The reactivity of the two injection sites is the same for such mixtures. The larger area made available by the use of the body skin may, therefore, be expected to yield results comparable with those obtained by Veldee's method.

For titration of toxins and the residual in formalinized toxins, the ear reactions have proved easier to evaluate than skin reactions.