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Development of Precipitins for Protein, Lipoid and Carbohydrate Fractions of S and R Forms of Tubercle Bacilli

Department of Bacteriology, Queen's University, Kingston, Canada

Abstract

Complement-fixation had shown that there were antigenic differences between the S and R forms of the tubercle bacillus, the precipitation tests recorded in this paper indicate small differences in the protein and carbohydrate substances in S and R organisms, although both chemical groups have common fractions. Lipoid fractions show no type specificity.

During the process of immunization with killed S tubercle bacilli, there is a relative increase in precipitins for proteins and carbohydrates from S organisms over that of precipitins for R proteins and carbohydrates. R antisera on the other hand increased in relative reactivity with R protein.

S antisera reacted relatively more strongly with purified globulin and polysaccharide preparations made from virulent cultures of human tubercle bacilli than did R antisera. The latter gave a relatively stronger reaction with purified albumin.

Footnotes

¹ This work was carried out by the author during the tenure of a Travelling Fellowship granted by the Royal Society of Canada for 1932–1933.

The author wishes to express her appreciation of the courtesies extended by Professor Dean and the staff of the Department of Pathology, University of Cambridge, England, where part of this work was carried out, and to Professor Reed of this Department her thanks for his many suggestions.