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Note on the Distribution and Solubility of M and N

Evans Memorial (Massachusetts Memorial Hospitals), Boston, Massachusetts

Abstract

I. Absence of M and N in Spermatazoa. In contrast to the wide distribution of A and B in the human body, M and N have not been found in muscle or saliva (1, 7). In view of the interesting suggestion of Lattes (4), based on the occurrence of A and B in spermatazoa, that the inheritance of A and B might be cytoplasmic rather than chromosomal, it seemed of interest to examine spermatazoa for M and N. Two specimens of spermatazoa from men of type O + - and two from O - + were centrifuged, washed, and covered with a small amount of a mixture of anti-M and anti-N testing fluids, as described in (1). On testing later with M and N erythrocytes, there was no evidence of removal of any agglutinin.