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An Agglutination Reaction Observed with Some Human Bloods, Chiefly Among Negroes

From the Laboratories of The Rockefeller Institute for Medical Research, New York City, and the Rockland State Hospital, Orangeburg, New York

Abstract

In an attempt to produce immune sera for the human blood property (1) designated as P two batches of 12 rabbits each were injected with the blood of individuals known to give strong reactions for P. The first batch received blood of the type O, M, N of a white man L. F., the second that of a Negro C. H. (O, N), the latter having been used for the preparation of anti-P-serum once before. The animals received several courses of six daily injections of 0.1 to 0.4 cc. washed blood cells in a volume of 1 cc. The courses were separated by rest periods of eight days; a fourth course of injections was given ten weeks after the third. From the first lot of rabbits, after three courses of injections, one P serum of moderate strength and two rather weak sera were obtained.