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The Formation of Precipitin for the Group a Specific Carbohydrate of Streptococcus Hemolyticus in Rabbits Injected Intravenously and Subcutaneously

From the Department of Medicine, College of Physicians and Surgeons, Columbia University, and the Presbyterian Hospital, New York City

Abstract

The variations in antibody formation following the injection of bacterial suspensions by different routes have been studied by a number of workers, but few of these reports have dealt with antibodies to specific bacterial carbohydrates. Julianelle (1) studied the latter problem in 1930 and found that 53 out of 60 rabbits immunized by repeated intracutaneous injections of small doses of heat-killed type I pneumococci failed to develop type-specific antibodies in their serum, while the remaining seven rabbits showed a very low titier of these antibodies. The sera of all sixty animals contained a high titer of antibody to the speciesspecific protein of Pneumococcus. The animals which failed to develop the type-specific carbohydrate antibody after intracutaneous injection still possessed "the ability to form type-specific antibodies when they were subsequently given intravenous inoculations of type-specific pneumococci." Francis and Tillett (2) subsequently reported similar results.