HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Kahn, R. L. Articles by McDermott, E. B. Search for Related Content PubMed Articles by Kahn, R. L. Articles by McDermott, E. B.

Studies on Tissue Reactions in Immunity

XV. Union Between Specific Antigen and Skin of Protein-Immunized Rabbits

From the Department of Bacteriology and the Laboratories of the University Hospital, University of Michigan, Ann Arbor

Abstract

Introduction In a recent report from this laboratory (1), a method was described which makes possible the study of some aspects of the union between specific antigen and the skin of horse serum-immunized rabbits. The method embraces the interplay between two types of immune reactions: diphtheria toxin with antitoxin and horse serum antigen with the skin of horse serumimmunized rabbits. The method is an indirect one, being based on the observation that horse serum diphtheria antitoxin does not possess the same neutralizing range for diphtheria toxin in normal and in horse serum-immunized rabbits in vivo. If a lethal amount of diphtheria toxin and its neutralizing quantity of antitoxin are injected some distance apart into the skin of both a normal rabbit and a horse serum-immunized rabbit, the former animal will survive and the immunized one will succumb. In the normal rabbit, the toxin and the antitoxin apparently diffuse from the area of injection and neutralization of the toxin takes place in vivo.