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Division of Experimental Bacteriology, The Mayo Foundation, Rochester, Minnesota
Abstract
Studies on the bacteriology (10) of various diseases, and on focal infection, (6, 8, 11, 14, 17, 21) have shown that streptococci with elective localizing power were often highly sensitive to oxygen and other requirements for growth in the primary culture, and that when these streptococci were cultivated on artificial mediums in the usual way they promptly lost specific localizing power, and somewhat more slowly general virulence and antigenic specificity (16). Hence, cultures made by usual methods, of material from open foci, such as tonsils, pyorrheal pockets, the nasopharynx, the prostate gland, the uterine cervix, and the nasal accessory sinuses, may yield the easily cultivable saprophytic organisms, including streptococci, instead of the highly sensitive, disease-producing strains. Moreover, cultures made in this way may result in no growth when material from involved tissues and closed foci such as apices of pulpless teeth, is used for inoculation of culture mediums.
Footnotes
1 Read before the American Association of Immunologists, Washington, D. C., May 9, 1933.
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