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Studies on Vascularization of the Cornea¹

II. Sensitization of the Cornea of Rabbits to Proteins

From the Oscar Johnson Institute, Washington University School of Medicine, Saint Louis, Missouri

Abstract

1. It has been possible to show that the corneal reaction of clouding and vascularization may accompany hypersensitiveness to protein.

2. Native (egg albumin) and bacterial (Bact. granulosis and Staphylococcus aureus) proteins are equally effective in inducing the corneal reaction.

3. Heightened corneal activity follows repeated, periodic injections of proteins by any route, but it occurs most regularly and vigorously following direct intracorneal injections.

4. There is no constant relationship between corneal reactivity, skin reactivity and circulating precipitins.

5. There is no constant relationship between activity of the cornea receiving the repeated injections and the activity of the previously uninoculated cornea.

Footnotes

¹ Conducted under a grant from the Commonwealth Fund of New York City.