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Studies on Tissue Reactions in Immunity

XI. Comparative Response Following Intravenous and Intradermal Injections of Organisms

From the Department of Bacteriology, and the Laboratories of the University Hospital, University of Michigan, Ann Arbor

Abstract

In the previous article (1) quantitative data were presented dealing with the degree of skin sensitivity in rabbits following sensitizing injections of bacterial vaccines. This sensitivity was subsequently found to be influenced by the method of administering the sensitizing injections. When administered intravenously, antibody formation seemed to exceed the response toward hypersensitiveness, whereas if administered intradermally, the hypersensitive response appeared to be the outstanding one. Another aspect was observed in connection with the sensitization of rabbits to bacterial suspensions, namely, that frequently repeated injections did not increase the sensitivity of rabbits to the same extent as infrequent injections. This article will briefly consider 2 experiments. In one, a group of rabbits was injected with typhoid vaccine, some intracutaneously and others intravenously, and the skin sensitivity and serum agglutinins were determined at definite intervals.