HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Seegal, B. C. Articles by Khorazo, D. Search for Related Content PubMed Articles by Seegal, B. C. Articles by Khorazo, D.

Local Organ Hypersensitiveness

V. The Fate of Antigen and the Appearance of Antibodies During the Development of Hypersensitiveness in the Rabbit Eye

From the Departments of Bacteriology and Medicine, College of Physicians and Surgeons, Columbia University and the Presbyterian Hospital, New York City

Abstract

The injection of small amounts of a foreign protein into the anterior chamber of the rabbit's eye produces an altered reaction capacity in this organ. After an appropriate incubation period the intravenous injection of the same antigen results in a transitory inflammatory response in the prepared eye. This was first demonstrated by Kummel (1), Fuchs and Meller (2), Von Szily (3) and by Riehm (4). Seegal and Seegal (5) studied the phenomenon, using a number of different antigens and established certain facts from which they inferred that the inflammatory eye response was the result of an antigen antibody reaction. The three main reasons for such a conclusion were: (a) an incubation period of at least five days is necessary before the reaction in the eye can be demonstrated. (b) The reaction is highly specific since only the protein injected into the eye will produce the local response on subsequent intravenous injection.