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H and O Agglutination in Typhoid Fever, Other Febrile Diseases, and in Vaccination

From the Department of Bacteriology, University of Tennessee, College of Medicine, and School of Biological Sciences, Memphis

Abstract

The qualitative receptor analysis of Weil and Felix (1), and Felix (2) for the serodiagnosis of typhoid fever has received little attention in this country. Since the incidence of typhoid fever in this especial locality offers unusual opportunities for such a study, the qualitative receptor analysis has been applied to a series of patients in the Memphis General Hospital who were suffering from typhoid fever and other febrile diseases, and to healthy vaccinated individuals. In all, 243 serums were studied and the results of these tests are presented in the tables which follow.

Felix (2) claims to be able to differentiate the agglutination reaction produced by infection from the one which follows the administration of typhoid vaccine on the basis of the type of macroscopic clumping obtained. The motile bacilli of the typhoid-paratyphoid group possess the double receptor apparatus originally described for the proteus bacilli, which indicates two important antigenic components, the H and O.