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The Immunologic Specificity of Brain Tissue

From the Otho S. A. Sprague Memorial Institute and the Department of Pathology, University of Chicago

Abstract

1. Suspensions of foreign brain tissue are strongly antigenic when injected into rabbits.

2. A suspension of rabbit brain is not antigenic for the rabbit.

3. Alcoholic extracts of all brains, including those of rabbit brain, are antigenic for the rabbit when activated with a foreign protein.

4. Brain antisera produced with a suspension of brain tissue and those produced with an activated alcoholic extract of brain are indistinguishable as to their content of antibodies that react with organs.

5. Brain antisera do not react with suspensions or alcoholic extracts of liver, kidney, heart, spleen and lungs of homologous or of all heterologous species tested. Neither do they react with blood serum.

6. Brain antisera react strongly with both the suspension and alcoholic extract of the brains of a group of animals representing mammals, birds, and cold-blooded types.

7. The brains of all animals tested are indistinguishable by complement fixation reactions with an antibrain serum.

8. Brain antisera react strongly with either the suspension or alcoholic extract of the testes of homologous and of all heterologous species tested.

9. There is no qualitative difference between the reaction of a suspension and an alcoholic extract of brain, or between a suspension and an alcoholic extract of testes with an anti-brain serum.

10. The spinal cord and all anatomical parts of the brain react similarly with an antibrain serum.

11. Lecithin (Merck's egg) does not react with an antibrain serum. Cholesterol (commercial) gives marked reactions.

This article has been cited by other articles:

				S. D. YEH, W. F. SEIP, C. BURCH, and F. W. BARNES Jr. Tissue Specificity of Serum Components Arch Intern Med, June 1, 1959; 103(6): 933 - 948. [Abstract] [PDF]