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The Antigenic Property of Gelatin-Diazo-Arsanilic Acid

From the Department of Immunology, Evans Memorial, Massachusetts Memorial Hospitals, and Boston University School of Medicine

Abstract

A serum obtained after injections of gelatin-diazo-arsanilic acid precipitated and fixed alexin in the presence of other proteins coupled with arsanilic acid, and its reactivity was specifically inhibited by phenol-diazo-arsanilic acid and by the gelatin compound itself. The latter did not react visibly with the antiserum.

The results indicate that antigenicity may be conferred upon gelatin by coupling it with an unsaturated cyclic compound; they do not show that the non-antigenicity of gelatin is due solely to its deficiency in aromatic amino-acids; the possibility that other prosthetic groups may be similarly effective has not been excluded.

On the basis of certain quantitative relationships observed, the suggestion is offered that some diazo-proteins may produce two or more specifically different anti-haptens.