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A Specific Reaction of Convalescent Serum on the Streptococcus Isolated in Studies of Poliomyelitis¹

Division of Experimental Bacteriology, The Mayo Foundation, Rochester, Minnesota

Abstract

A specific reaction of convalescent poliomyelitis serum on the streptococcus isolated in studies of poliomyelitis is reported.

By studying the effect of convalescent serum on the streptococcus having characteristic cataphoretic velocity as isolated in cases of poliomyelitis, a marked and specific slowing or chargereducing effect has been discovered. This action of the serum increases during recovery from poliomyelitis, and is at its maximum during the fourth week after onset of the acute attack, after which there is gradual diminution, but it remains readily demonstrable even twenty years after recovery. The reaction is specific in that the serum of persons and monkeys who have recovered from typical attacks, affects both the strains from cases in human beings and in monkeys in that streptococci and other bacteria from sources other than poliomyelitis are not affected, and in that the reacting antibodies can be removed by absorption only with the streptococcus from poliomyelitis. The results indicate that the streptococcus isolated by us so consistently in poliomyelitis is not a contamination or an agonal or post-mortem invader.

Footnotes

¹ Read before the American Association of Immunologists, Philadelphia, Pennsylvania, April 27, 1932.