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Studies in Anaphylaxis in the Rabbit

IV. On the Simonds Explanation of the Different Pathology of Acute Anaphylactic Shock in Different Animal Species

V. On the Role of Unstriped Muscle in Acute Anaphylaxis in the Rabbit

From the Department of Bacteriology in Cornell University Medical College, the New York Hospital, New York, and the Robert Koch Institute, Berlin

Abstract

The experiments described in this paper confirm the well established rôle of unstriped muscle in acute anaphylactic shock in the rabbit. They also confirm the view of Simonds and of Wells that the difference in the pathology of acute anaphylaxis in the guinea pig and rabbit are due to differences in the structural relations in the respective shock organs because both bronchial and arterial muscle in the same animal (guinea pig) have been shown capable of specific contraction and therefore both contract during acute anphylactic shock; yet in the one situation the contraction results in closure of the lumen, whereas in the other, it does not.