HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Grove, E. F. Search for Related Content PubMed Articles by Grove, E. F.

Studies in Anaphylaxis in the Rabbit¹

I. A Study of the Factors Concerned in the Establishment of Maximal Hypersensitiveness in Rabbits to Egg White and Horse Serum

From the Department of Bacteriology in Cornell University Medical College, the New York Hospital, New York City, and the Robert Koch Institute, Berlin

Abstract

1. Of 53 rabbits treated with the Grove series of injections with egg white (described in the text), 70 per cent were made maximally sensitive to intravenous test, 5.6 per cent exhibited slight symptoms of anaphylaxis and 24.4 per cent failed to show any symptoms. Similar results were obtained with horse serum.

2. Variations in the number or the selected routes of the injections lessened the effectiveness of the treatment in establishing anaphylactic sensitiveness in the animals.

3. The established sensitiveness persists for at least two or three weeks.

4. An additional subcutaneous injection given one week after the period of highest sensitiveness usually causes no diminution in the concentration of the blood-borne antibodies; nevertheless the sensitiveness of the animals is always greatly diminished or entirely extinguished.

5. Active sensitization of rabbits does not depend entirely upon the degree of antibody productivity because animals showing a high power of antibody production may be wholly insensitive and vice versa.

Footnotes

¹ The work reported in this series of papers was carried out in part in the Robert Koch Institute, Berlin under the tenure of the first scholarship of the Gardiner School Alumnae Association of New York City.