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The Mouse Protection Test on Antipneumococcic Serum Type I

From the Lederle Laboratories, Inc., Pearl River, New York

Abstract

In evaluating the potency of antipneumococcic sera, the mouse protection test, based on the work of Neufeld (1) and that done at the Rockefeller Institute (2), has been extensively used, and has been prescribed by the Public Health Service (3), for the standardization of antipneumococcic serum type I. The minimum standard of potency as established in the official test is that 0.2 cc. of serum must protect at least 50 per cent of the mice injected against 0.1 cc. of virulent type I culture, this dose of culture being equivalent to about 10 million fatal doses of culture.

The New York State minimum standard (4) is essentially the same as the of the Public Health Service, but in actual practice the test has been somewhat modified. For example, 0.1 cc. of serum is often used in the serum-culture mixtures injected in the test mice as well as 0.2 cc.; also, 0.2 and 0.3 cc. doses of culture are used as well as the 0.1 cc. dose.