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Further Attempts to Transfer the Immunological Response of Tuberculous Animals

From the Department of Pathology and Bacteriology of the Massachusetts General Hospital, Boston, Massachusetts

Abstract

Three groups of experimental efforts to transfer to other animals the increased immunologic response of tuberculous animals have been described. The transfer of tuberculous omenta or tuberculous peritoneal exudate, a few minutes after the injection of egg-white, to the peritoneal cavity of normal pigs was unsuccessful. Where a similar transfer was made into the peritoneal cavity of a previously infected animal—in a stage of infection in which the injection of egg-white alone does not produce the characteristic effect—irregular positive results were obtained. A simultaneous injection of egg-white and tubercle bacilli was in these guinea pigs often successful.

The experiments suggest that two factors are involved, (a) the effect which the lesion itself produces upon the antigen, and (b) a certain preparation of the organism as a whole occurring during the course of the infection.