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Attempts to Produce General or Local Hypersensitivity to Vaccinia Virus in Guinea Pigs Actively or Passively Immunized

From the Department of Bacteriology, College of Physicians and Surgeons, Columbia University

Abstract

The literature relating to the production of specific antibodies in the various virus diseases has been unusually contradictory. However, the trend of current research would seem to indicate that the various antibodies which may be demonstrated as the result of simple infection or hyperimmunization with bacterial antigens can be duplicated with most viruses. Regardless of the cumulative evidence presented in recent years, it cannot be denied that there are obstacles which undoubtedly hinder the demonstration of serological reactivity with antivirus serums in a manner unknown with antibacterial immune serums. The intracellular habitat of viruses has probably been one of the reasons for the lack of similarity and uniformity in the results since in almost all immunological tests these causative agents have not yet been satisfactorily divorced from the animal or plant tissues in which they are propagated.