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An Improved Diluent for Diphtheria Toxin in the Schick Test

From the Antitoxin and Vaccine Laboratory of the Massachusetts Department of Public Health

Abstract

1. An improved method is described for preparing diphtheria toxin ready diluted for the Schick test.

2. Diphtheria toxin diluted to Schick strength (1/5 M.L.D. per cubic centimeter) with an aqueous solution of Witte peptone 0.25 per cent, sodium chloride 0.85 per cent and phenol 0.5 per cent and passed through a Berkefeld filter retains its toxicity even after ninety-six hours' incubation at 37.5°C.

3. The reactions following the injection into human beings of this ready-diluted toxin and of toxin freshly diluted, as in the previous Schick outfits, are entirely comparable.

4. The use of 0.25 per cent Witte peptone is preferable to 2 per cent Difco-Proteose peptone because of its failure to produce early or diffuse reactions.