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Transmission to the Third Generation of Antitoxin Derived by Active Immunization of the First Generation

From the Department of Bacteriology and Immunology, Vanderbilt University Medical School, Nashville, Tennessee

Abstract

A guinea pig of the second generation transmitted to its own offspring (third generation) small amounts of antitoxin originally derived by active immunization of the first generation. Previous reports of failure of transmission were probably due to quantitative inadequacy of the immunity originally transmitted to the females of the second generation to persist to the time of birth of the third generation.