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A Determination of Amounts of Antitoxic Globulin Solution Effective in Sensitizing a Guinea Pig; the Amount of Cross Sensitization between Antitoxic Globulin or Serum Obtained from the Horse, the Goat and the Calf¹

From the Bacteriological Department of Bellevue Medical College

Abstract

Introduction. In December, 1923, Dr. Sanford Hooker made a report showing that skin sensitiveness to horse proteins was apparently increased after completion of the series of toxin-antitoxin injections then used in immunization against diphtheria. The toxin-antitoxin was a mixture of 3 L + preparation and contained about 0.01 ml. of serum. The test dose demonstrating skin sensitiveness given six months later contained 0.005 ml. of serum (4). Dr. William H. Park partially corroborated this, but found much less difference, stating that in his observations while increased skin sensitiveness was demonstrable, it was only of moderate extent and then not a serious contraindication to serum therapy, since in his experience a larger number of severe results after therapeutic doses of serum had not ensued in children after immunization with the small amount of antitoxin at present used with the 0.1 L + dose in active immunization than in control groups of children who had never received toxin-antitoxin (5).

Footnotes

¹ Submitted in partial fulfillment of the requirements for the degree of Master of Science at New York University.