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The Colloidal Gold Test in Experimental Poliomyelitis¹

Department of Bacteriology, College of Physicians and Surgeons, Columbia University, New York City

Abstract

Samples of spinal fluid taken from poliomyelitis monkeys on the day of the onset of symptoms, show with considerable regularity, i.e., in 75 per cent of the cases, a colloidal gold curve characterized by a well-marked elevation in the second third or middle of the series of dilutions. The curve thus seems to fall into the so-called luetic zone, although the reactions were, as a rule, not as pronounced as in syphilis. As the infectious process progresses, there appears a change in the curve which manifests itself either as a shift forward, or in most cases, as a complete flattening out to a curve which is practically indistinguishable from the reaction of the normal monkey spinal fluid. Any possible diagnostic value of the test in the monkey would thus be limited very largely to the earliest stages of the disease. Whether this subsequent change in the type of curve is related to a characteristic development of the pathologic condition in the central nervous system or whether it has any bearing on the possible presence or absence of the virus in the fluid, we are unable to state at present. Another interesting feature of this work seems to us to lie in the close similarity between our results and those recorded by other investigators for poliomyelitis in the human, thus indicating the far reaching analogy between the original human disease and the experimentally produced infection.

Footnotes

¹ Under a grant from the Milbank Fund for the study of infantile paralysis. Read at the meeting of the American Association of Immunologists April 16–17, 1930, New York City.