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On the Heatstability of the Scarlet Fever and Diphtheria Toxins¹

Preliminary Report

From the Bacteriological Department, Hygienic Institute (Director S. Kanai), Dairen

Abstract

The thermostability of scarlet fever toxin has been dealt with by many authors and this property is one of the reasons that aroused suspicion as to the exotoxic nature of this toxin and also as to the toxin-antitoxin theory of the Dicks. There are many reports that even boiled Dick toxin (scarlet fever streptococcus culture filtrate) is capable of eliciting skin reactions in human beings if it is used in a dose corresponding to 1 or more skin test doses. But it must be noted that positive reactions to a dose of boiled toxin corresponding to 1 S.T.D. seem to have been found mainly by those authors who employed a streptococcus filtrate toxin containing blood element.

Footnotes

¹ Read before the eighth meeting of the Japanese Medical Association (Section of Microbiology), Osaka, April 2, 1930.