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The Reaction of the Human Skin to Normal and Immune Guinea Pig Serum

From the Research Institute of Cutaneous Medicine, Philadelphia

Abstract

1. The human skin reacts rather regularly, with the immediate type of reaction, to normal guinea pig serum in a dilution of 1:10, and to a lesser degree to one of 1:50.

2. Usually, after this reaction, the skin becomes normal in appearance in two to twenty-four hours.

3. When an anti-human serum in a dilution of 1:10 is injected, the immediate reaction is not always greater than that due to the normal serum. But a difference is made more evident by using higher dilutions of the sera, indicating a specific antigen-antibody response.

4. A further difference in the reactions is seen in the persistence of that to the immune serum, with induration and inflammation for twenty-four hours.

5. The degree of the reaction, with both sera, is only slightly reduced by heating the sera for ten minutes at 50°C.