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Renaissance of Pre-Ehrlich Immunology¹

From the Laboratory of Bacteriology and Experimental Pathology, Stanford University, California

Abstract

1. There is convincing evidence that injected antigens undergo a series of chemical "hybridizations" in animal tissues, and suggestive evidence that the resulting antigen-tissue "hybrids" become semi-permanently "symbiotic" with these tissues, both terms, of course, being used metaphorically.

2. Whether or not these "symbiotic hybrids" are to be regarded as partially homologized antigens, as specifically alienated somatic proteins (30), or as antigen-somatic-protein conjugates can not be predicted from present biochemical knowledge.

3. There is convincing evidence that some of these antigen-tissue "hybrids" have properties simulating those of specific antibodies, but no proof thus far that they are identical with these antibodies.

4. There is, however, no evidence at the present time that there is any other physiological method of specific antibody formation.

Footnotes

¹ Presented before the Joint Session of the American Association of Immunologists and the American Association of Pathologists and Bacteriologists, New York City, April 17, 1930.

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				W. H. Manwaring POST-EHRLICH IMMUNOLOGY Science, October 2, 1931; 74(1918): 324 - 327. [Abstract] [PDF]