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Allergic Reactions in Vaccinia-Immune Rabbits

From the Department of Bacteriology, College of Physicians and Surgeons, Columbia University

Abstract

1. Evidence is given to indicate that allergic reactions do occur in a certain percentage of vaccinia-immune rabbits.

2. Some evidence is given indicating that the reactions obtained may be partly due to homologous testicle tissue reacting with organ specific antibodies. That the virus does play some part in the reaction is indicated by the fact that the reactions are much greater in virus immune animals than in animals immune only to testicle tissue.

3. While a state of hyperimmunity tends to reduce the amount of induration in the allergic reaction, there is no conclusive evidence that the negative results in some animals are due to this hyperimmunity.

4. The chief factor determining the occurrence or non-occurrence of an allergic reaction is the individual factor in the animal.

5. From apparently successful passive transfer,—general and local—of the allergic state and from the apparent acceleration of vaccinal reactions by treatment with immune serum, it seems probable that the allergic reactions are the result of antigenantibody reactions.

6. Evidence in a human subject of a local factor in the allergic reaction indicates that the antigen-antibody reaction concerned does not entirely depend upon antibodies in the serum.

Footnotes

¹ Work partly completed under tenure of a Fellowship in Medicine from the National Research Council.