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This Article Full Text Full Text (PDF) Data Supplement All Versions of this Article: jimmunol.0900641v1 183/5/3364    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Related articles in The JI Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Google Scholar Articles by Cheung, K. P. Articles by Goldrath, A. W. PubMed PubMed Citation Articles by Cheung, K. P. Articles by Goldrath, A. W.

Memory-Like CD8⁺ T Cells Generated during Homeostatic Proliferation Defer to Antigen-Experienced Memory Cells¹

University of California, San Diego, Division of Biological Sciences, La Jolla, CA 92093

Naive T cells proliferate in response to lymphopenia and acquire the phenotypic and functional qualities of memory T cells, providing enhanced protection against infection. How well memory-like T cells generated during lymphopenia-induced homeostatic proliferation (HP)-memory differentiate into secondary memory cells and compete with Ag-experienced true-memory cells is unknown. We found that CD8⁺ HP-memory T cells generated robust responses upon infection and produced a secondary memory population comparable to true-memory cells in the absence of competition. However, when true-memory and HP-memory T cells competed during infection, HP-memory cells contributed less to the effector population, contracted earlier, and formed fewer secondary memory cells. Furthermore, HP- and true-memory cells demonstrated distinct chemokine receptor expression and localization within the spleen during infection, indicating differential access to signals necessary for secondary memory formation. Thus, HP-memory T cells provide protection without compromising the true-memory population. Differences in HP- and true-memory T cells may reveal the basis of competition for limited resources within the memory-T cell compartment.

The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

¹ This work was supported by grants from the National Institutes of Health (R01AI67545), Cancer Research Institute, and Pew Scholars Program (A.W.G.), the University of California, San Diego Cellular and Molecular Genetics Training Grant (K.P.C.) and the Chancellor’s Research Scholarship (E.Y.).

² Address correspondence and reprint requests to Dr. Ananda W. Goldrath, University of California, San Diego, Division of Biological Sciences, 9500 Gilman Drive, La Jolla, CA 92093-0377. E-mail address: agoldrath{at}ucsd.edu

³ Abbreviations used in this paper: HP, homeostatic proliferation; DC, dendritic cell; Lm.OVA, recombinant Listeria monocytogenes expressing ovalbumin; MZ, marginal zone; OVAp, peptide derived from OVA_(257–264); PALS, periarteriolar lymphoid sheath; qPCR, quantitative PCR; RP, red pulp.

⁴ The online version of this article contains supplemental material.

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The JI 2009 183: 2889-2890. [Full Text]