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Coronin 1 Is Essential for IgM-Mediated Ca²⁺ Mobilization in B Cells but Dispensable for the Generation of Immune Responses In Vivo¹

Benoit Combaluzier^*, Philipp Mueller^*, Jan Massner^*, Daniela Finke and Jean Pieters^2,*

^* Biozentrum and Department of Clinical Biological Sciences, University of Basel, Basel, Switzerland

Coronin 1 is a leukocyte specific regulator of Ca²⁺-dependent signaling and is essential for the survival of peripheral T lymphocytes, but its role in B cells is unknown. In this study, we show that coronin 1 is essential for intracellular Ca²⁺ mobilization and proliferation upon triggering of the BCR. However, the presence of costimulatory signals rendered coronin 1 dispensable for B cell signaling, consistent with the generation of normal immune responses against a variety of Ags in coronin 1-deficient mice. We conclude that coronin 1, while being essential for T cell function and survival, is dispensable for B cell function in vivo.

The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

¹ This work was supported by grants from the Swiss National Science Foundation (to D.F. and J.P.) and the Olga Mayenfisch Stiftung, the Swiss Life Jubilaeumsstiftung, and the Canton of Basel-Stadt (to J.P.).

² Address correspondence and reprint requests to Dr. Jean Pieters, Biozentrum, University of Basel, Klingelbergstrasse 70, Basel, Switzerland. E-mail address: jean.pieters{at}unibas.ch

³ Abbreviation used in this paper: PNA, peanut agglutinin.

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