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Cutting Edge: Phenotypic Characterization and Differentiation of Human CD8⁺ T Cells Producing IL-17¹

Division of Viral Immunology, Center for AIDS Research, Kumamoto University, Kumamoto, Japan

Although IL-17-producing CD8⁺ T cells (Tc17 cells) have recently been identified, the detailed information about these cells still remains unclear. In this article we describe a study investigating the phenotype and differentiation of human Tc17 cells. Human Tc17 cells were detected in a minor population of CD8⁺ T cells and were predominantly found in CD27^–/+CD28⁺CD45RA^– memory subsets. They also expressed CCR6 and a high level of CCR5. Though most Tc17 cells produced IFN-, a small part of the Tc17 cell population was IFN- negative in some individuals. Analysis of the in vitro induction of Tc17 cells showed that these cells were induced from the CD27⁺CD28⁺CD45RA⁺ naive subset and that they expressed the CD27^–CD28⁺CD45RA^– and CCR6⁺ phenotype. These results together indicate that Tc17 cells have a unique phenotype and suggest that they differentiate from the same precursors that differentiate into IFN--producing CD8⁺ T cells.

The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

¹ This research was supported by Grant-in Aid for Scientific Research 17047033 from the Ministry of Education, Science, Sports, and Culture of the government of Japan.

² T.K. and H.T. contributed equally to this work.

³ Address correspondence and reprint requests to Dr. Masafumi Takiguchi, Division of Viral Immunology, Center for AIDS Research, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan. E-mail address: masafumi{at}kumamoto-u.ac.jp

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