HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Morris, S. C. Articles by Finkelman, F. D. Search for Related Content PubMed PubMed Citation Articles by Morris, S. C. Articles by Finkelman, F. D.

Endogenously Produced IL-4 Nonredundantly Stimulates CD8⁺ T Cell Proliferation¹

Suzanne C. Morris^*,, Stephanie M. Heidorn^*,, De'Broski R. Herbert^*,, Charles Perkins^*,, David A. Hildeman, Marat V. Khodoun^*, and Fred D. Finkelman^2,*,,

^* Research Service, Cincinnati Veterans Affairs Medical Center, Cincinnati, OH 45220; Division of Immunology, University of Cincinnati College of Medicine, Cincinnati, OH 45267; and Division of Immunobiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229

T cell proliferation and survival are regulated by the cytokine receptor common -chain-associated cytokines IL-2, IL-7, and IL-15, while IL-4, another -chain-associated cytokine, is thought to primarily affect T cell quality rather than quantity. In contrast, our experiments reveal that endogenously produced IL-4 is a direct, nonredundant, and potent stimulator of CD8⁺ T cell proliferation in Ag- and pathogen-induced CD8⁺ T cell responses. These stimulatory effects of IL-4 are observed in both BALB/c and C57BL/6 mice and activate both naive and memory/activated phenotype CD8⁺ T cells, although the former are stimulated less than are the latter. IL-4 effects are IL-7- and IL-15-independent, but MHC class I-dependent stimulation appears to be required for the mitogenic effect of IL-4 on naive phenotype CD8⁺ T cells. Thus, endogenously produced IL-4 is an important regulator of quantitative as well as qualitative aspects of T cell immunity.

The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

¹ This work was supported by a Merit Award from the Department of Veterans Affairs and National Institutes of Health Grants R01 AI052099, R01 AI072040, and R01 GM083204.

² Address correspondence and reprint requests to Dr. Fred D. Finkelman, Division of Immunology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267. E-mail address: ffinkelman{at}pol.net

³ Abbreviations used in this paper: _c, common -chain; GAMD, goat anti-mouse IgD antiserum; LCMV, lymphocytic choriomeningitis virus.