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Cutting Edge: Antigen Presentation to CD8 T Cells after Influenza A Virus Infection¹

Elizabeth Ingulli^2,*, Castle Funatake, Erica L. Jacovetty^* and Maurizio Zanetti^2,

^* Department of Pediatrics and Laboratory of Immunology, Department of Medicine and Moores Cancer Center, University of California San Diego, La Jolla, CA 92093

Influenza A virus infection induces massive inflammation and lung damage. Activation of CD8 T cells by dendritic cells (DCs) is necessary to control disease. We undertook studies to track directly Ag presentation to CD8 T cells in vivo through the first 72 h after infection with OVA-expressing influenza A virus. We found that Ag presentation by DCs occurs strictly in the draining lymph nodes and not within the lung itself. Surprisingly, Ag presentation was found to be mediated by a CD11b⁺ DC population. Finally, the expression of antigenic complexes on DCs correlated with the location and timing of CD8 T cell activation. These results have implications for approaches to control influenza A virus infection.

The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

¹ This work was supported by National Institutes of Health Grants R21-AI069836 (to E.I.), 5T32AI060536 (to C.F.), and RO1AI062894 (to M.Z.).

² Address correspondence and reprint requests to Dr. Elizabeth Ingulli or Dr. Maurizio Zanetti, University of California, San Diego, 9500 Gilman Drive MC0815, La Jolla CA 92093-0815. E-mail addresses: eingulli{at}ucsd.edu and mzanetti{at}ucsd.edu

³ Abbreviations used in this paper: DC, dendritic cell; i.n., intranasal(ly).

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