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Human Memory B Lymphocyte Subsets Fulfill Distinct Roles in the Anti-Polysaccharide and Anti-Protein Immune Response¹

Leen Moens^*, Margareta Wuyts^*, Isabelle Meyts, Kris De Boeck and Xavier Bossuyt^2,*

^* Experimental Laboratory Medicine, Department of Medical Diagnostic Sciences, Group Biomedical Sciences, Catholic University, Leuven, Belgium; and Department of Pediatrics, University Hospital, Leuven, Belgium

There is controversy on the role of IgM memory and switched memory B lymphocytes in the Ab response to T cell-independent and T cell-dependent Ags. We transplanted SCID/SCID mice with human B lymphocyte subsets and immunized them with heat-inactivated Streptococcus pneumoniae or with a pneumococcal vaccine. Inactivated S. pneumoniae and soluble pneumococcal capsular polysaccharides elicited an IgM anti-polysaccharide and anti-protein Ab response from IgM memory B lymphocytes and an IgG anti-polysaccharide and anti-protein response from switched memory B lymphocytes. In addition to the IgM Ab response, IgM memory B cells elicited an IgG anti-polysaccharide and anti-protein Ab response after immunization with inactivated S. pneumoniae or soluble pneumococcal capsular polysaccharides. In conclusion, our findings provide evidence for a versatile role of IgM memory B cells in T-independent and T-dependent immune responses.

The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

¹ This work was supported by a grant from the Fund for Scientific Research-Flanders. X.B. is a senior clinical investigator of the Fund for Scientific Research-Flanders.

² Address correspondence and reprint requests to Dr. Xavier Bossuyt, Laboratory Medicine, Immunology, GHB-Herestraat 49, B-3000 Leuven, Belgium. E-mail address: xavier.bossuyt{at}uz.kuleuven.ac.be

³ Abbreviations used in this paper: TI, T cell independent; caps-PS, capsular polysaccharide; PspA, pneumococcal surface protein A; sIg, surface Ig; TD, T cell dependent; TI-2, TI type 2.

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The JI 2008 181: 5179-5180. [Full Text]  

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