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Plasmacytoid Dendritic Cells Take Up Opsonized Antigen Leading to CD4⁺ and CD8⁺ T Cell Activation In Vivo¹

Pia Björck^2,*, Andreas Beilhack^3,, Edward I. Herman, Robert S. Negrin and Edgar G. Engleman^*

^* Department of Pathology/Stanford Blood Center and Department of Medicine, Division of Blood and Marrow Transplantation, Stanford University, Palo Alto, CA 94304

Plasmacytoid dendritic cells (pDC) are the body’s main source of IFN-, but, unlike classical myeloid DC (myDC), they lack phagocytic activity and are generally perceived as playing only a minor role in Ag processing and presentation. We show that murine pDC, as well as myDC, express Fc receptors (CD16/CD32) and can use these receptors to acquire Ag from immune complexes (IC), resulting in the induction of robust Ag-specific CD4⁺ and CD8⁺ T cell responses. IC-loaded pDC stimulate CD4⁺ T cells to proliferate and secrete a mixture of IL-4 and IFN-, and they induce CD8⁺ T cells to secrete IL-10 as well as IFN-. In contrast, IC-loaded myDC induce both CD4⁺ and CD8⁺ T cells to secrete mainly IFN-. These results indicate that pDC can shape an immune response by acquiring and processing opsonized Ag, leading to a predominantly Th2 response.

The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

¹ This work was supported by Grants AR051748 (to E.G.E.) and CA80006 (to R.S.N.).

² Address correspondence and reprint requests to Dr. Pia Björck, Stanford University, Department of Pathology/Stanford Blood Center, 3373 Hillview Avenue, Palo Alto, CA 94304. E-mail address: bjorck{at}stanford.edu

³ Current address: Department of Medicine II, Würzburg University, Würzburg, Germany.

⁴ Abbreviations used in this paper: pDC, plasmacytoid dendritic cell; DC, dendritic cell; IC, immune complex; myDC, myeloid DC; Tg, transgenic.

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