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SCART Scavenger Receptors Identify a Novel Subset of Adult T Cells¹

Jan Kisielow^2,*, Manfred Kopf^* and Klaus Karjalainen

^* Molecular Biomedicine, Institute of Integrative Biology, Swiss Federal Institute of Technology (ETH), Zürich-Schlieren, Switzerland and Nanyang Technological University, School of Biological Sciences, Singapore

Although there has been great progress in the characterization of β T cell differentiation, selection, and function, T cells have remained poorly understood. One of the main reasons for this is the lack of T cell-specific surface markers other than the TCR chains themselves. In this study we describe two novel surface receptors, SCART1 and SCART2. SCARTs are related to CD5, CD6, and CD163 scavenger receptors but, unlike them, are found primarily on developing and mature T cells. Characterization of SCART2 positive immature and peripheral T cells suggests that they undergo lineage specification in the thymus and belong to a new IL-17-producing subset with distinct homing capabilities.

The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

¹ J.K. was supported by the Swiss National Science Foundation Grant No.3100A0-100351. K.K was supported by Biomedical Research Council Grant 06/1/22/19/469.

² Address correspondence and reprint requests to Dr. Jan Kisielow, Molecular Biomedicine, Swiss Federal Institute of Technology (ETH), Zürich, Wagistrasse 27, CH-8952 Zürich-Schlieren, Switzerland. E-mail: jan.kisielow{at}env.ethz.ch

³ Abbreviations used in this paper: DETC, dendritic epidermal T cell; DN, double negative; DP, double positive; EST, expressed sequence tag; HA, hemagglutinin; HSA, heat-stable Ag; KO, knockout; LN, lymph node; RTE, recent thymic emigrant; SRCR, scavenger receptor cysteine-rich (domain).