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Cutting Edge: Migration of Langerhans Dendritic Cells Is Impaired in Autoimmune Dermatitis¹

Anna U. Eriksson,^* and Ram Raj Singh^2*

^*Department of Medicine and Department of Pathology and Laboratory Medicine, Autoimmunity and Tolerance Laboratory, David Geffen School of Medicine, University of California, Los Angeles, CA 90095

Tissue-resident dendritic cells, such as Langerhans cells (LC), normally carry Ags from tissues to lymph nodes to induce immunity to tissue Ags. In this study, we report that LC are reduced in the skin-draining lymph nodes of MRL-Fas^lpr/lpr and MRL-Fas^+/+ mice that develop T cell-mediated autoimmune skin inflammation as compared with MHC-matched healthy strains. This deficiency of LC in skin-draining lymph nodes is due to a profound impairment of LC migration, resulting in the accumulation of activated LC in the skin. Such a defect in LC migration develops before the onset of skin lesions and correlates with the onset and severity of dermatitis. The reduced, rather than increased, migration of LC from skin to skin-draining lymph nodes represents a novel functional abnormality of LC in autoimmune dermatitis.

The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

¹ This work was supported by National Institutes of Health Grants AR47322, AR50797, and AR56465. A.E. is a recipient of the Meyer Investigator Award from the Arthritis Foundation of Southern California.

² Address correspondence and reprint requests to Dr. Ram Raj Singh, 1000 Veteran Avenue, Room 32-59, Los Angeles, CA 90095. E-mail address: RRSingh{at}mednet.ucla.edu

³ Abbreviations used in this paper: DC, dendritic cell; B6, C57BL/6; B6-lpr, C57BL/6-Fas^lpr/lpr; C3H, C3H/HeOuJ; CLN, cutaneous lymph node; LC, Langerhans cells; mDC, myeloid DC; MRL^+/+, MRL/MpJ-Fas^+/+; MRL-lpr, MRL/MpJ-Fas^lpr/lpr.

⁴ The online version of this article contains supplemental material.

This article has been cited by other articles:

				J. A. Fulcher, M. H. Chang, S. Wang, T. Almazan, S. T. Hashimi, A. U. Eriksson, X. Wen, M. Pang, L. G. Baum, R. R. Singh, et al. Galectin-1 Co-clusters CD43/CD45 on Dendritic Cells and Induces Cell Activation and Migration through Syk and Protein Kinase C Signaling J. Biol. Chem., September 25, 2009; 284(39): 26860 - 26870. [Abstract] [Full Text] [PDF]