HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Cook, L. Articles by Born, W. K. Search for Related Content PubMed PubMed Citation Articles by Cook, L. Articles by Born, W. K.

Evidence That CD8⁺ Dendritic Cells Enable the Development of T Cells That Modulate Airway Hyperresponsiveness¹

Laura Cook^*, Nobuaki Miyahara, Niyun Jin^*, J. M. Wands^*, Christian Taube, Christina L. Roark^*, Terry A. Potter^*, Erwin W. Gelfand, Rebecca L. O'Brien^* and Willi K. Born^2,*

^* Department of Immunology and Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206

Airway hyperresponsiveness (AHR), a hallmark of asthma and several other diseases, can be modulated by T cells. In mice sensitized and challenged with OVA, AHR depends on allergen-specific β T cells; but V1⁺ T cells spontaneously enhance AHR, whereas V4⁺ T cells, after being induced by airway challenge, suppress AHR. The activity of these T cell modulators is allergen nonspecific, and how they develop is unclear. We now show that CD8 is essential for the development of both the AHR suppressor and enhancer T cells, although neither type needs to express CD8 itself. Both cell types encounter CD8-expressing non-T cells in the spleen, and their functional development in an otherwise CD8-negative environment can be restored with transferred spleen cell preparations containing CD8⁺ dendritic cells (DCs), but not CD8⁺ T cells or CD8^– DCs. Our findings suggest that CD8⁺ DCs in the lymphoid tissues enable an early step in the development of T cells through direct cell contact. DC-expressed CD8 might take part in this interaction.

The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

¹ This work was supported by National Institutes of Health Grants AI40611 and HL65410 to W.K.B., AI44920 and AI063400 to R.L.O., and HL36577 to E.W.G.

² Address correspondence and reprint requests to Dr. W. K. Born, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206. E-mail address: bornw{at}njc.org

³ Abbreviations used in this paper: AHR, airway hyperresponsiveness; DC, dendritic cell; MCh, methacholine; PALS, periarteriolar lymphoid sheath.

This article has been cited by other articles:

				Y. Huang, N. Jin, C. L. Roark, M. K. Aydintug, J. M. Wands, H. Huang, R. L. O'Brien, and W. K. Born The Influence of IgE-Enhancing and IgE-Suppressive {gamma}{delta} T Cells Changes with Exposure to Inhaled Ovalbumin J. Immunol., July 15, 2009; 183(2): 849 - 855. [Abstract] [Full Text] [PDF]

				N. Jin, C. L. Roark, N. Miyahara, C. Taube, M. K. Aydintug, J. M. Wands, Y. Huang, Y.-S. Hahn, E. W. Gelfand, R. L. O'Brien, et al. Allergic Airway Hyperresponsiveness-Enhancing {gamma}{delta} T Cells Develop in Normal Untreated Mice and Fail to Produce IL-4/13, Unlike Th2 and NKT Cells J. Immunol., February 15, 2009; 182(4): 2002 - 2010. [Abstract] [Full Text] [PDF]