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B Cell Chemoattractant CXCL13 Is Preferentially Expressed by Human Th17 Cell Clones¹

Rie Takagi^*, Takehiro Higashi^*, Kumiko Hashimoto^*, Kazuhisa Nakano^*,, Yosuke Mizuno, Yasushi Okazaki and Sho Matsushita^2,*

^* Department of Allergy and Immunology, Faculty of Medicine, Division of Functional Genomics and Systems Medicine, Research Center for Genomic Medicine, Saitama Medical University, Saitama, and First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan

Th 17 cells represent a novel subset of CD4⁺ T cells that have a protective effect against extracellular microbes, while they are also responsible for autoimmune disorders in mice. However, the protein expression profile of Th17 cells remains to be clarified. In this study, we report an effective method to establish human allo-reactive Th17 cell clones and demonstrate that human Th17, but not Th1 or Th2, cells express B cell chemoattractant CXCL13, by using DNA chips, RT-PCR, and ELISA. Such a pattern was also the case in Candida albicans-specific Th17 clones and synovial fluid specimens obtained from patients with rheumatoid arthritis. The biological implication of this finding is discussed.

The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

¹ This work was supported in part by an Internal Research Grant from Saitama Medical University and a Research Grant-In-Aid for Scientific Research by the Ministry of Health, Labor and Welfare of Japan, the Ministry of Education, Culture, Sports, Science and Technology of Japan.

² Address correspondence and reprint requests to Dr. Sho Matsushita, Department of Allergy and Immunology, Faculty of Medicine, Saitama Medical University, 38 Morohongo, Moroyama, Saitama 350-0495, Japan. E-mail address: shomat{at}saitama-med.ac.jp

³ Abbreviations used in this paper: Mo-DC, monocyte-derived dendritic cells; OA, osteoarthritis; RA, rheumatoid arthritis.

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