HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Clémenceau, B. Articles by Vié, H. Search for Related Content PubMed PubMed Citation Articles by Clémenceau, B. Articles by Vié, H. Pubmed/NCBI databases Substance via MeSH

Effector Memory β T Lymphocytes Can Express FcRIIIa and Mediate Antibody-Dependent Cellular Cytotoxicity¹

Béatrice Clémenceau^*,, Régine Vivien^*,, Mathilde Berthomé^*,, Nelly Robillard, Richard Garand, Géraldine Gallot^*,, Solène Vollant^*, and Henri Vié^2,*,

^* Institut National de la Santé et de la Recherche Médicale, Unité 601, Nantes, France; l’Université Nantes, Nantes, France; and Laboratoire d’Hématologie, Centre Hospitalier de l’Université Nantes, Nantes, France

Human memory T cells are comprised of distinct populations with different homing potential and effector functions: central memory T cells that mount recall responses to Ags in secondary lymphoid organs, and effector memory T cells that confer immediate protection in peripheral tissues. In the present study we demonstrate that a proportion of effector memory T cells express FcRIIIa (CD16), are perforin positive, and directly mediate Ab-dependent cytotoxicity ex vivo. This particular β T lymphocyte subset has the morphology of large granular lymphocytes, increases proportionately in vivo during reactive lymphocytosis, and can be detected in vitro among EBV-specific T lymphocytes after stimulation with EBV Ags. Consequently, during a normal immune response, amplification of these effector memory T lymphocytes that are capable of Ab-dependent cytotoxicity may have beneficial or harmful consequences depending on the presence of pathogen- or tissue-specific Abs, respectively.

The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

¹ B.C. was supported by Association Francaise Contre les Myopathies.

² Address correspondence and reprint requests to Dr. Henri Vié, Institut National de la Santé et de la Recherche Médicale, Unité 601, 9 Quai Moncousu, 44093 Nantes cedex, France. E-mail address: hvie{at}nantes.inserm.fr

³ Abbreviations used in this paper: ADCC, Ab-dependent cellular cytotoxicity; BLCL, B lymphoblastoid cell line; LGL, large granular lymphocyte.