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NKT Cells in Tumor Immunity: Opposing Subsets Define a New Immunoregulatory Axis¹

Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892

NKT cells are true Ag-specific T cells that also have innate properties and form a bridge between the innate and adaptive immune systems. Distinct NKT cell subsets play positive and negative regulatory roles and define a new immunoregulatory axis with broad implications for tumor immunity and other immunological and disease settings.

The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

¹ This work was supported in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We apologize for not citing all works on the topic because of space limitations.

² Address correspondence and reprint requests to Dr. Masaki Terabe or Dr. Jay A. Berzofsky, Vaccine Branch, National Cancer Institute, Building 10, Room 6B-12, Bethesda, MD 20892-1578. E-mail address: terabe{at}mail.nih.gov or berzofsk{at}helix.nih.gov

³ Abbreviations used in this paper: DC, dendritic cell; GalCer, -galactosylceramide; EAE, experimental autoimmune encephalitis; KO, knockout; Treg, T regulatory (cell).