HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Barcy, S. Articles by Corey, L. Search for Related Content PubMed PubMed Citation Articles by Barcy, S. Articles by Corey, L.

⁺ T Cells Involvement in Viral Immune Control of Chronic Human Herpesvirus 8 Infection¹

Serge Barcy^2,*, Stephen C. De Rosa^*, Jeffrey Vieira^*, Kurt Diem^*, Minako Ikoma^*, Corey Casper and Lawrence Corey^*,,

^* Department of Laboratory Medicine and Department of Medicine, University of Washington and Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle WA 98109

Little is known about what effector populations are associated with the control of human herpesvirus 8 (HHV-8) infection in vivo. We compared T lymphocyte subsets among HIV^–HHV-8⁺ and HIV^–HHV-8^– infected human individuals. β⁺ T cells from HHV-8-infected individuals displayed a significantly higher percentage of differentiated effector cells among both CD4⁺ and CD8⁺ T cell subsets. HHV-8 infection was associated with significant expansion of ⁺ V1 T cells expressing a differentiated effector cell phenotype in peripheral blood. In vitro stimulation of PBMC from HHV-8-infected individuals with either infectious viral particles or different HHV-8 viral proteins resulted in V1 T cell activation. In addition, V1 T cells displayed a strong reactivity against HHV-8-infected cell lines and prevented the release of infectious viral particles following the induction of lyric replication. These data indicate that T cells play a role in both innate and adaptive T cell responses against HHV-8 in immunocompetent individuals.

The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

¹ This work was supported by National Institutes of Health Grants AI30731, R37 AI42528, RO1 DE016809, RO1 DE14149, and K23 AI054162-04. This research was also supported by the University of Washington Center for AIDS Research, a National Institutes of Health-funded program (P30 AI 27757).

² Address correspondence and reprint requests to Dr. Serge Barcy, Department of Laboratory Medicine, University of Washington, 1959 Northeast Pacific Street, P.O. Box 358070, Seattle, WA 98109. E-mail address: sbarcy{at}u.washington.edu

³ Abbreviations used in this paper: HHV-8, human herpesvirus 8; HVS, Herpesvirus saimiri; KSHV, Kaposi’s sarcoma associated herpesvirus; ORF, open reading frame; PEL, primary effusion lymphoma; rh, recombinant human.

This article has been cited by other articles:

				L. Li and C.-Y. Wu Response: Human memory but not naive {gamma}{delta} T cells from TST-positive individuals respond to M tuberculosis antigen Blood, December 1, 2008; 112(12): 4777 - 4777. [Full Text] [PDF]