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CD22 Regulates Time Course of Both B Cell Division and Antibody Response¹

Taishi Onodera^*,, Jonathan C. Poe, Thomas F. Tedder and Takeshi Tsubata^2,*,,

^* Laboratory of Immunology, School of Biomedical Science, and Department of Immunology, Medical Research Institute, Tokyo Medical and Dental University, and Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Tokyo, Japan; and Department of Immunology, Duke University Medical Center, Durham, NC 27710

Because pathogens induce infectious symptoms in a time-dependent manner, a rapid immune response is beneficial for defending hosts from pathogens, especially those inducing acute infectious diseases. However, it is largely unknown how the time course of immune responses is regulated. In this study, we demonstrate that B cells deficient in the inhibitory coreceptor CD22 undergo accelerated cell division after Ag stimulation, resulting in rapid generation of plasma cells and Ab production. This finding indicates that CD22 regulates the time course of B cell responses and suggests that CD22 is a good target to shorten the time required for Ab production, thereby augmenting host defense against acute infectious diseases as "universal vaccination."

The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

¹ This work was supported in part by grants from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, Japan Society for the Promotion of Science, and the Program for Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation.

² Address correspondence and reprint requests to Dr. Takeshi Tsubata, Laboratory of Immunology, School of Biomedical Science, and Department of Immunology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan. E-mail address: tsubata.imm{at}mri.tmd.ac.jp

³ Abbreviations used in this paper: B6.Ly5.1, Ly5-congenic C57BL/6; AFC, Ab-forming cell; NP, 4-hydroxy-3-nitrophenyl acetyl; CGG, chicken -globulin; GC, germinal center; HEL, hen egg white lysozyme; NIP, 4-hydroxy-3-iodo-5-nitrophenyl acetyl; PNA, peanut agglutinin.