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Cell Intrinsic TGF-β1 Regulation of B Cells¹

Aix Marseille Université, Faculté des Sciences de Luminy, Centre d’Immunologie de Marseille-Luminy, Institut National de la Santé et de la Recherche Médicale U631, Centre National de la Recherche Scientifique Unité Mixte de Recherche 6102, Marseille, France

TGF-β family cytokines play multiple roles in immune responses. TGF-β1-null mice suffer from multi-organ infiltration that leads to their premature death. T cells play a central role in the TGF-β1 phenotype, as deficiency of TGF-β1 only in T cells reproduces the lethal phenotype. Although it is known that TGF-β1 controls B cells isotype switch and homeostasis, the source responsible for this control has not been characterized. Because of the major role that T cells play in regulating B cell responses, we addressed the T cell dependency of the TGF-β1 control of B cells. The analysis of T cell-deficient, TGF-β1 knockout mice and the production of chimeras in which B but not T cells lacked TGF-β1 allowed us to show that B cells are controlled in part by cell autonomous production of TGF-β1.

The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

¹ This work was supported by institutional funding from Institut National de la Santé et de la Recherche Médicale and Centre National de la Recherche Scientifique. M.J.G. was financed by a grant from the Ministère de la Recherche and from Fondation pour la recherche médicale.

² Address correspondence and reprint requests to Dr. Rodolphe R. Guinamard, Centre d’Immunologie de Marseille-Luminy, Campus de Luminy, Case 906, 13288, Marseille, Cedex 09, France. E-mail address: guinamard{at}ciml.univ-mrs.fr

³ Abbreviations used in this paper: KO, knockout; LN, lymph node; MLN, mesenteric LN; Sp, spleen; PC, peritoneal cavity; BM, bone marrow; Treg, regulatory T cell; WT, wild type.