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* Department of Dermatology,
Department of Gynecology and Obstetrics,
Department of Pathology,
Department of Urology, Tongji Hospital,
¶ Department of Biochemistry and Molecular Biology, and
|| Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Condylomata acuminata derived from the infection of human papillomavirus is a common sexually transmitted disease. Although T cell-mediated cellular immunity is considered as the main arm against such infection, the regulation of T cell immune responses in genital condylomata is unclear to date. In this study, we analyzed FOXP3+ regulatory T cells in genital condylomata of patients. The results show that FOXP3+ regulatory T cells with suppressive function accumulated in large warts. Consistently, the immunosuppressive milieu in large warts was characterized by high expression of IL-10 and TGF-β1 and low expression of IL-2 and IFN-
. The responsiveness of wart-infiltrating T cells both in vitro and in vivo can be increased by depleting FOXP3+ T cells. The accumulation of FOXP3+ regulatory T cells in large warts can be partly ascribed to the chemotaxis of CCL17 and CCL22, derived from Langerhans cells and macrophages in wart. Although such accumulation favors the local immunosuppression, it seems not to influence the systemic immunity. In conclusion, these findings demonstrate that FOXP3+ regulatory T cells play an important role in genital condylomata, which has multiple implications in the comprehensive treatment of condylomata acuminata.
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
1 This work was supported in part by the National Natural Science Foundation of China (No. 30772589 and No. 30771974).
2 Y. C. and J. Z. contributed equally to this work.
3 Address correspondence and reprint requests to Dr. Bo Huang, Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. E-mail address: tjhuangbo{at}hotmail.com
4 Abbreviations used in this paper: CA, condylomata acuminata; HPV, human papillomavirus; LC, Langerhans cell; Treg, regulatory T cell; CY, cyclophosphamide.
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 M. R. Goldstein, L. Mascitelli, and F. Pezzetta Comment on "Local Accumulation of FOXP3+ Regulatory T Cells: Evidence for an Immune Evasion Mechanism in Patients with Large Condylomata Acuminata" J. Immunol., October 1, 2008; 181(7): 4433 - 4433. [Full Text] [PDF]
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Y. Cao, J. Zhao, and B. Huang Response to Comment on "Local Accumulation of FOXP3+ Regulatory T Cells: Evidence for an Immune Evasion Mechanism in Patients with Large Condylomata Acuminata" J. Immunol., October 1, 2008; 181(7): 4433 - 4434. [Full Text] [PDF]
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