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The Effect of the Injection of Colloidal Substances on Experimental Typhus Fever

From the Department of Medicine, Peiping Union Medical College, Peiping, China

Abstract

Many studies have been made to ascertain the effect of the injection of various colloidal substances on the reticulo-endothelial system particularly in regard to the influence on immunity or on the production of demonstrable immune bodies. It is well known that colloidal substances when injected either intravenously or intraperitoneally are rapidly taken up by the endothelial cells. The whole endothelial system takes part in the process but by far the greatest amounts of the substances are found in the reticulo-endothelial cells of the liver, spleen, lungs, lymph nodes and bone marrow (1) (2). It seemed of interest therefore to observe the effect of the injection of certain colloidal substances on typhus fever, a disease which involves chiefly the endothelial cells.

Typhus fever is characterized by proliferative and degenerative changes in the smaller blood vessels of the skin and viscera (3).