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A Case of Pel Ebstein's Syndrome of Tuberculous Origin¹

From the Department of Pathology, Cornell University Medical College, and the Memorial Hospital, New York City

Abstract

Among the various clinical types of Hodgkin's disease, there is a rather rare form in which gradual splenic enlargement with intermittent attacks of pyrexia, lasting for two weeks or longer, are the most prominent features, the associated lymph node involvement being either absent or insignificant.

This peculiar syndrome was first described by Murchison in 1871, but received very little attention. Pel, in 1885, described three similar cases as pseudoleukemia. This was followed in 1887 with a detailed report by Ebstein of a new infectious disease. From time to time isolated cases of this form of Hodgkin's disease have been reported by Symmers (1909), Wade (1913), Mellon (1916) and the author (1924).

In the further study of the experimental inoculation of chickens with Hodgkin's nodes, a case of Hodgkin's disease with the Murchison-Pel-Ebstein's syndrome was submitted to me from the Memorial Hospital:

The patient was a young man, twenty-five years of age, from the British West Indies.

Footnotes

¹ Read before the American Association of Immunologists, The American Association of Pathologists and Bacteriologists, Chicago, Illinois, March 27, 1929.