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Skin Reactions Produced by Antihuman Serum¹

Department of Medicine, University of Chicago

Abstract

1. A pronounced twenty-four-hour local reaction follows injection of rabbit antihuman serum into human skin.

2. This reaction is almost identical with that produced by a second injection of antigen into a previously sensitized local area.

3. Microscopically, both are seen to be inflammatory in nature, showing edema and perivascular round cell infiltration.

4. Fractionation of immune serum with ammonium sulphate shows that the skin reactive substances are closely associated with the globulins are are also the precipitins. Removal of the precipitins, however, fails to destroy the skin reacting properties.

5. The albumin fraction of rabbit serum fails to incite an immediate urticarial reaction in human skin as does the globulin.

6. Persons who show clinical manifestations of hypersensitiveness do not show stronger skin reactions than non-sensitive persons.

7. Five patients from the series of 68 injected showed a local delayed reaction comparable to that of serum sickness.

Footnotes

¹ This work has been conducted under a grant from the Douglas Smith Foundation for Medical Research of the University of Chicago.