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The Toxicity of Human Serum for the Guinea Pig As Affected by Absorption of Agglutinins

From the Research Institute of Cutaneous Medicine, Philadelphia

Abstract

1. Sera from persons treated with immune sera and showing a toxicity of the heterophilic type for the guinea pig, when treated with the red cells of this animal for the removal of agglutinins do not lose such toxicity.

2. When the same sera are absorbed in the same way with sheep cells, as a heterophilic antigen, the toxicity is usually but not always completely, removed thereby.

3. The experiments further indicate the heterophilic nature of the antibodies concerned in the toxicity. But there is also the possibility that, in these cases, sheep cells constitute an incomplete antigen; or else that another factor, as yet unidentified, is contained in such sera.