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T Cells1
* Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206;
University of Colorado at Denver Health Sciences Center, Denver, CO 80262; and
Bolder BioPATH, University of Colorado, Boulder, CO 80309
Murine 
T cell subsets, defined by their V chain usage, have been shown in various disease models to have distinct functional roles. In this study, we examined the responses of the two main peripheral T cell subsets, V1+ and V4+ cells, during collagen-induced arthritis (CIA), a mouse model that shares many hallmarks with human rheumatoid arthritis. We found that whereas both subsets increased in number, only the V4+ cells became activated. Surprisingly, these V4+ cells appeared to be Ag selected, based on preferential V4/V4 pairing and very limited TCR junctions. Furthermore, in both the draining lymph node and the joints, the vast majority of the V4/V4+ cells produced IL-17, a cytokine that appears to be key in the development of CIA. In fact, the number of IL-17-producing V4+ T cells in the draining lymph nodes was found to be equivalent to the number of CD4+
+ Th-17 cells. When mice were depleted of V4+ cells, clinical disease scores were significantly reduced and the incidence of disease was lowered. A decrease in total IgG and IgG2a anti-collagen Abs was also seen. These results suggest that V4/V4+ T cells exacerbate CIA through their production of IL-17.
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
1 This work was supported by an Investigator Award from the Arthritis Foundation (to C.L.R.), an award from the American Heart Association (to J.D.F.), and by National Institutes of Health Grants 2R01 A1044920 (to R.L.O.) and 2R01 HL65410 (to W.K.B.).
2 Address correspondence and reprint requests to Dr. Christina L. Roark, Integrated Department of Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, K409, Denver, CO 80206. E-mail address: roarkc{at}njc.org
3 Abbreviations used in this paper: CIA, collagen-induced arthritis; RA, rheumatoid arthritis; CII, type II collagen.
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