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A Y Chromosome-Linked Factor Impairs NK T Development¹

Johnna D. Wesley^2,*, Marlowe S. Tessmer^2,*, Christophe Paget, François Trottein and Laurent Brossay^3,*

^* Department of Molecular Microbiology and Immunology and Graduate Program in Pathobiology, Division of Biology and Medicine, Brown University, Providence, RI 02912; and Centre d’Immunologie et Biologie Parasitaire, Institut Pasteur de Lille, Lille, France

V14 invariant (V14i) NK T cell development is unique from mainstream T cell selection, and the polygenic factors that influence NK T cell ontogeny are still unclear. In this study, we report the absence of V14i NK T cells in B6.IFN-R1^–/– male mice, whereas both the conventional T and NK cell populations are relatively unaffected. The lack of V14i NK T cells in the B6.IFN-R1^–/– males is not due to an insufficient level of CD1d1 or a defect in CD1d1-Ag presentation, but it is intrinsic to the male V14i NK T cells. This surprising defect displays 99% penetrance in the male population, whereas female mice remain unaffected, indicating the deficiency is not X linked. Analysis of the V14i NK T cell compartment in B6.Tyk2^–/–, B6.STAT1^–/–, 129.IFN-R1^–/–, and B6.IFN-R1^–/+ mice demonstrate that the deficiency is linked to the Y chromosome, but independent of IFN-. This is the first study demonstrating that Y-linked genes can exclusively impact V14i NK T development and further highlight the unique ontogeny of these innate T cells.

The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

¹ This work was supported by National Institutes of Health Research Grants AI46709 and AI058181 to L.B.

² J.D.W. and M.S.T. contributed equally to this work.

³ Address correspondence and reprint requests to Dr. Laurent Brossay, Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Box G-B618, Brown University, Providence, RI 02912.

⁴ Abbreviations used in this paper: V14i, V14 invariant; -GalCer, -galactosylceramide; DN, double negative; DP, double positive; HSA, heat stable Ag; SP, single positive.

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The JI 2007 179: 3389-3390. [Full Text]  

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